Effect of lithium on muscarinic cholinoceptor-stimulated phosphoinositide-specific phospholipase C substrate selectivity in CHO-m1 cells.
نویسندگان
چکیده
Phosphoinositidc-specific phospholipase C (PI-PLC) activity is stiinulatcd by a variety of hormones, neurotransmitters and growth factors to generatc inositol 1,4,5-trisphosphate (Ins( 1,4,S)P3) and sri-. 1 ,?-diacylglycerol (DAG) from phosphatidylinositol 4.5bisphosphatc (PtdInsPZ) [ I ] . In studies examining the activation o f ph(.sphoinositide turnover by receptors linked to PI-PLC activity via gu.ininc nuclcotidc binding proteins, evidence has generally bccn ob.aincd t o support the view that PI-PLC prefcrcntially hyrolyscs Ptdl nsP2 ovcr phosphatidylinositoI4-monophosphate (PtdlnsP) and phl sphatidylinositol (Ptdlns) [2-4].
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 23 3 شماره
صفحات -
تاریخ انتشار 1995